1. Discovery and optimization of chemical probes to define important molecular signals in medicine.
  2. Nature Reviews Drug Discovery article:   Chemical modulators of S1P receptors as barrier-oriented therapeutic molecules.   
  3. Nature Chemical Biology article: S1P1 signaling just keeps going and going and going…   
  4. Nature Biotechnology article:   Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes.   
Home » MLPCN

MLPCN

The Molecular Libraries Probe Centers Network (MLPCN) is the full production phase replacement to the MLSCN. There are 4 large centers nationwide of which Scripps is one. Together with 5 speciality centers they comprise the MLPCN, a part of the NIH's strategic funding plan, the Roadmap Initiative.

To read the NIH MLPCN announcement, click here.

Assays are screened against compound libraries from the Molecular Libraries Small Molecule Repository (MLSMR). Information about the assays and molecules screened by the MLPCN is published to the PubChem public database.

Further information can be obtained from the following links;

MLSCN MLPCN

MLI MLI

MLSMR MLSMR

PubChem PubChem
 

History (Pilot Phase)

The Molecular Libraries Screening Centers Network (MLSCN) was launched on June 15, 2005 as part of the Molecular Libraries Initiative (MLI). The MLSCN consisted of 10 screening centers with The Scripps Research Institute a leading member of the network.

MLSCN

 

Useful Links

Eli Lilly and NCGC Assay Guidance Manual

Documents & Definitions

Access to MLPCN Screening

FAQs for the MLPCN
 


Copyright (c) 2008 TSRI.